Cell Systems-Modular Viral Scaffolds for Targeted Bacterial Population Editing

Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing

Hiroki Ando1, Sebastien Lemire1, Diana P. Pires1,2, Timothy K. Lu1
1 Department of Electrical Engineering and Computer Science and Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
2 Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Cell Systems, Volume 1, Issue 3, 23 September 2015, Pages 187–196
DOI: http://dx.doi.org/10.1016/j.cels.2015.08.013
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A synthetic biology strategy to modulate phage host ranges by engineering phage genomes in Saccharomyces cerevisiae. This innovative approach could potentially accelerate phage biology studies and enable new technologies for bacterial population editing.